In vitro experiments demonstrated that LJCP-2b affected TNF-α-induced rheumatoid arthritis fibroblast-like synoviocyte (RA-FLS) functions, including attenuation of cell viability, increase in apoptosis, decrease in the number of migratory movements and adhesion capacity, and reduction in the levels of IL-6 and IL-1β. Here, TNF is linked to rheumatoid arthritis.