NFKB1 and rheumatoid arthritis: The aim of this review is to provide a comprehensive overview of current research involving plant polysaccharides, animal polysaccharides and microbial polysaccharides, the therapeutic rheumatological activity of polysaccharides from different sources and their mechanisms, with a particular focus on the relevant signaling pathways for the treatment of RA, NF-κB, PI3K/AKT, JAK/STAT and MAPK.