An in vitro and in vivo study of the therapeutic effects of ASP on RA showed that ASP inhibited TNF-α-induced phosphorylation of components of the JAK2/STAT3 and MAPK signaling pathways in CIA-FLS cells.ASP also inhibited inflammatory cytokine invasion and secretion via JAK2/STAT3 and MAPK signaling by FLS cells from CIA rats (106). Here, TNF is linked to rheumatoid arthritis.