TNF and staphylococcus aureus infection: In the colon, cimifugin mainly acts on cytokine-cytokine receptor interaction, cysteine and methionine metabolism, Hippo signaling pathway, TGF-β signaling pathway, cellular senescence, glycolysis, and JAK-STAT signaling pathway (Figure 6A), whereas in the lung, cimifugin mainly affected cytokine-cytokine receptor interaction, PI3K-Akt signaling pathway, TNF signaling pathway, JAK-STAT signaling pathway, IL-17 signaling pathway, Staphylococcus aureus infection, cellular senescence, PPAR signaling pathway (Figure 6B).