TJP1 and lung disorder: Although there are no studies on the effects of cimifugin on lung diseases, demonstrated that cimifugin reduced the expression of the above chemokines and their receptors, inhibited the enrichment of M1 macrophage in the colon and lungs, and upregulated the expression of tight junction proteins, such as ZO-1 and Occludin, suggesting that cimifugin restores the structure and function of the epithelial barrier and maintains immune homeostasis in both organs.