IL4 and Alzheimer disease: Although cytokines such as IL-4, IL-13, and IL-17A have been shown to induce epidermal hyperplasia (11, 30, 31), stratification of AD patients based on IL-4, IL-13, or IL-17A production by HDM-activated CLA+ memory T cells (Supplementary Figure S3A) was insufficient to account differences in epidermal thickness between subgroups (Supplementary Figure S3B).