In MS patients’ CSF, we identified one major cluster composed of four sub-clusters [cluster 1a (mostly chemokines and growth factors): G-CSF, MIP-1α, IP-10, SDF-1α, HGF, IL-12, SCGF-β, CTACK, MIG, PDGF-BB, M-CSF, and SCF; cluster 1b (mostly pro-inflammatory): MIP-1β, TNF-α, IFN-γ, TNF-β, RANTES, IL-9, IL-17, and IL-12; cluster 1c (high proportion of anti-inflammatory cytokines): IL-1RA, IL-10, IL-13, IL-4, LIF, IL-15, VEGF, and GRO-α; and cluster 1d (mostly other cytokines): MIF, M-CSF, SCF, and IL-16]. Here, IL16 is linked to myeloid sarcoma.