NFATC2 and neoplasm: Unlike classical Ewing sarcoma, this tumour displays a characteristic FISH pattern with amplification at the 5′ end of the EWSR1 locus [17, 18] This is due to a genomic rearrangement that fuses the N-terminal transactivation domain of EWSR1 to the C-terminal DNA binding domain of NFATC2, and this fusion is often accompanied by amplification of the 5′ end of the EWSR1 locus.