The authorsreported a significant linear increase in GFAP over the study period, while no acutechanges in GFAP were observed following scrimmages, suggesting that astroglialactivation may accumulate over time even in the absence of concussion diagnoses.However, this longitudinal GFAP increase was not significantly associated withcumulative head impact burden calculated based on acceleration metrics frominstrumented mouth guards (82). The gene discussed is GFAP; the disease is concussion.