Despite this interesting finding which strongly supports Lp(a) as a risk factor for early atherosclerosis in HeFH patients, a very recent study of 143 young adults with HeFH (age 31.8 ± 3.2 years) failed to find an association with carotid arterial stiffness and Lp(a) levels (12). The gene discussed is LPA; the disease is atherosclerosis.