LPA and atherosclerosis: In addition, in a large cross-sectional study of 1,960 patients with HeFH and their 957 non-HeFH relatives, higher Lp(a) levels were found in those with HeFH, particularly in those with pre-existing ASCVD, compared to their non-HeFH relatives (14) suggesting that elevated Lp(a) levels predispose to a heightened risk of ASCVD in patients with HeFH.