Interestingly, the direction of effect varied by cell type: the IBD risk allele was associated with decreased FUBP1 expression in ADGRL3-expressing myofibroblasts, where FUBP1 may support epithelial regeneration and mucosal repair56, but increased expression in several immune cell types, including T cells and rectal cDC2s (Supplementary Figure S10). The gene discussed is ADGRL3; the disease is inflammatory bowel disease.