HLA-DRB1 and rheumatoid arthritis: Meta-analysis SNP rs679242 (6p21.32; HLA-DRB1) has been previously significantly associated with several diseases including rheumatoid arthritis (p=1.1×10−121), type 1 diabetes (p=4.6×10−63), and type 2 diabetes (p=2.8×10−14) (Table 3).