Neurological phenotypes such as lissencephaly, seizures, and severe intellectual disability are notably more prevalent in cases with MACF1 variants in the GAR domain, while craniofacial and skeletal phenotypes such as microcephaly, cleft palate, micrognathia, and clinodactyly are present in cases with MACF1 variants outside the GAR domain. This evidence concerns the gene MACF1 and lissencephaly spectrum disorders.