HIF1A and Alzheimer disease: Besides, several deregulated genes between PLum-AI and PLum-AD cells, presented in the Clustergram generated by Enrichr tool, such as PTGES, IL6, HIF1A, CCL7, TLR3, CCL2, TNF, and IL1A (all p < 0.02) are related to prostaglandins synthesis and their downstream signaling (Shen and Li, 2017; Pahl et al., 2007; Liu et al., 2018; Salvi et al., 2016; Finetti et al., 2020; Hinson et al., 1996; Dossus et al., 2010; Ja et al., 2021; Wang et al., 2022) (Figure 1C).