Given that the herbal medication naringenin can inhibit the PI3K/AKT pathway, as well as the ability of small molecule C-82 to inhibit the Wnt/β-catenin pathway, this work used to investigate the simultaneous inhibition of these two pathways in endometrial stem cells derived from the menstrual blood of EM patients. This evidence concerns the gene AKT1 and erythema multiforme.