LPS may stimulate and accelerate different signaling pathways MyD88/TRIF- AP-1/ MAPK, NF-Kappa B, β1AR, Ca2+ sensing receptor, HMGA1, trigger oxidative stress, which results in the release of multiple inflammatory cytokines, adhesion molecules, ROS, lead to impaired blood flow cardiac dysfunction, atherosclerosis, and myocardial infarction. This evidence concerns the gene HMGA1 and myocardial infarction.