CDKN2B and cancer: DNAm levels of naturally hypermethylated transposable repetitive elements (e.g., LINE-1 and Alu (24–27)) or tumor suppressor genes (e.g., CDKN2A (p16) and CDKN2B (p15) (24, 28, 29)) and oncogenes (e.g., MAGE-A1, H19, MLH1 and MSH2 (26, 28, 30, 31)) were historically used to inform about global methylation modifications in the body, and to make the link between exposure and cancer development.