TLR4 and pulmonary embolism: Our research results are as follows: 1) When acute pulmonary embolism combined with shock occurs, the lung tissue in the embolism area and non-embolism area is in a state of severe hypoxia, followed by the activation of the downstream TLR4/NF-κB/HIF-1α signaling pathway, HIF-1α further activates Gal-3 expression.