In the acute pulmonary embolism combined with shock model, the TLR4/NF-κB/HIF-1α pathway in the embolism area might be activated, promoting the occurrence of inflammatory response, stimulating the production of downstream inflammatory factors such as IL-6 and TNF-α, and aggravating pulmonary circulatory failure. The gene discussed is HIF1A; the disease is pulmonary embolism.