Numerous literature reports that elevated levels of Gal-3 are associated with poor prognosis and mortality of cardiovascular and cerebrovascular diseases such as pulmonary arterial hypertension, ARDS, acute myocardial infarction, and stroke (Tsai et al., 2012; Calvier et al., 2016; Hara et al., 2020; Sayed et al., 2022), and hemodynamic instability in the acute phase of acute pulmonary embolism is one of the main causes of short-term death, and irreversible shock leads to death in high-risk patients with pulmonary embolism (Quezada et al., 2019). This evidence concerns the gene LGALS3 and pulmonary arterial hypertension.