VKORC1L1 and cancer: •Vitamin K induces cell death in cancer models via apoptosis, autophagy, cell cycle arrest, and ferroptosis in select instances•Vitamin K can be converted to its reduced form (Vitamin K hydroquinone, KH2) by ferroptosis inhibitory protein 1 (FSP1), which prevents lipid peroxidation, reducing the amount of NAD(P)H available, thereby inhibiting ferroptosis•Vitamin K epoxide reductase complex subunit 1-like 1 (VKORC1L1) inhibits ferroptosis