NR4A1 and Carcinoma, Lewis Lung: found that tumor growth was significantly inhibited in Mice lacking NR4A1 and NR4A2 genes specifically in Tregs subcutaneously inoculated with Lewis lung carcinoma cells, and inhibition of NR4A1 in tumor-infiltrating regulatory T cells (TI-Tregs) breaks down the immune tolerance to tumor cells and promotes the antitumor activity of tumor-infiltrating CD8+ T cells (69).