HRG and neoplasm: Specifically, UGT1A10 exhibited a markedly elevated expression in tumor tissues, while the remaining nine hub genes (ADH1A, ADH1B, ADH1C, ADH4, SLC10A1, CYP2C9, GPT, HRG, and PON1) showed significantly reduced expression levels in cancerous tissues compared with their adjacent normal counterparts (Supplementary Figure S3E).