In our patient, the immunohistochemical profile was classic for leiomyosarcoma, with strong positivity for SMA, desmin, vimentin, and caldesmon, while negative for epithelial markers (cytokeratins), gastrointestinal stromal tumor markers (CD117, DOG-1), and other mesenchymal tumor markers (STAT6, SATB2). This evidence concerns the gene DES and gastrointestinal stromal tumor.