Primitive neuroectodermal tumors (PNETs) also warrant attention, given their histological similarities with Ewing's sarcoma.4, 5Discriminating between these entities relies on immunohistochemical analysis, which helps delineate their distinct molecular profiles as they express neuronal markers like neuron-specific enolase and synaptophysin. This evidence concerns the gene ENO2 and Ewing sarcoma.