EV is an autosomal recessive genetic disorder associated with mutations in two key genes; EVER1/TMC6 (Transmembrane Channel-like 6) located on chromosome 17q25.3 and EVER2/TMC8 (Transmembrane Channel-like 8) located on chromosome 17q25.3, adjacent to EVER1. The gene discussed is TMC8; the disease is epidermodysplasia verruciformis.