EV is an autosomal recessive genetic disorder associated with mutations in two key genes; EVER1/TMC6 (Transmembrane Channel-like 6) located on chromosome 17q25.3 and EVER2/TMC8 (Transmembrane Channel-like 8) located on chromosome 17q25.3, adjacent to EVER1. This evidence concerns the gene TMC6 and epidermodysplasia verruciformis.