In Brooke-Spiegler syndrome (BSS), which is characterized by multiple adnexal tumors, including cylindromas, spiradenomas, and trichoepitheliomas, a defect in the CYLD gene located on chromosome 16 at position 12.1 is typically observed [1]. Here, CYLD is linked to adnexal spiradenoma/cylindroma of a sweat gland.