CSRP1 and syphilis: While our in vitro knockdown and splicing inhibition experiments (Figure 2G,H and 4D–G) strongly support the functional role of CSRP1 and MYO10, the technical challenges of implementing CRISPR/Cas9 or shRNA‐based knockout approaches in the rabbit model—currently, the only syphilis pathology‐recapitulating system—precluded direct in vivo mechanistic verification.