Amylin, also known as human islet amyloid polypeptide (hIAPP), is an intrinsically disordered 37-residue peptide hormone, and its fibrillation is associated with T2D.3 hIAPP is an endocrine partner to insulin and is co-secreted with insulin in the pancreas.4 For reasons not yet fully understood, disruptions in cellular balance alter hIAPP-to-insulin ratio, leading to hIAPP fibrillation. Here, INS is linked to type 2 diabetes mellitus.