In secondary analyses, in models also adjusting for MAGGIC and NT-proBNP, adjusting for atrial fibrillation or HF duration ≥18 months yielded similar HRs, and interactions with atrial fibrillation or HF duration ≥18 months in models were also not statistically significant (phenogroup 2-atrial fibrillation P-interaction=0.13, phenogroup 3-atrial fibrillation P-interaction=0.49, overall P for interaction=0.32; phenogroup 2-HF duration P-interaction=0.39, phenogroup 3-HF duration P-interaction=0.30, overall P for interaction=0.53). The gene discussed is NPPB; the disease is atrial fibrillation.