For the β chain, many V/J genes, which were highly expressed in cachexic HCC mice, were associated with type I diabetes, such as Trbv1 [S18,19], Trbv13‐2 [S19], Trbj2‐7 [S19,20] and with Sjögren's syndrome, such as Trbv3 [S21], Trbv16 [S22] and Trbj2‐2 [S22]. Here, TRBV16 is linked to type 1 diabetes mellitus.