On the other hand, the CPu of the male TRPM2+/+ PD showed increased levels of IFNγ, IL‐1α, IL‐1β, IL‐6, and TNFα, while the female TRPM2+/+ PD presented increased levels of IFNγ, IL‐6, and TNFα {IFNγ: Injection × Genotype [F(2,24) = 8.923; p = 0.001]; IL‐1α: Injection × Genotype [F(2,24) = 2.978; p = 0.070]; IL‐1β: Interaction [F(11,24) = 3.954; p = 0.033]; IL‐6: Injection × Genotype [F(2,24) = 9.877; p = 0.001]; TNFα: Injection × Genotype [F(2,24) = 4.835; p = 0.017]}. This evidence concerns the gene IL1B and Parkinson disease.