In the TRPM2+/+ PD group, the area of CD68 was larger in both the SNc and the CPu of males and females (p = 0.000, for all comparisons), suggesting an enhancement in microglial phagocytic activity after PD induction {SNc: Injection × Genotype [F(2,239) = 32.387; p = 0.000]; CPu: Injection × Genotype [F(2,219) = 37.564; p = 0.000]}. The gene discussed is TRPM2; the disease is Parkinson disease.