In the CPu, 100% of the cells were allocated in cluster 1 for the TRPM2+/+ group; 97.1% of the cells were allocated in cluster 1 and 2.9% in cluster 2 for the TRPM2+/− group; 100% of the cells were allocated in cluster 1 for the TRPM2−/− group; 10% of the cells were allocated in cluster 1 and 90% in cluster 2 for the TRPM2+/+ PD group; 86.8% of the cells were allocated in cluster 1 and 13.2% in cluster 2 for the TRPM2+/− PD group; 90% of the cells were allocated in cluster 1 and 10% in cluster 2 for the TRPM2−/− PD group. The gene discussed is TRPM2; the disease is Parkinson disease.