SERPINB6 and central nervous system cancer: This finding aligns with our mechanistic hypothesis: since SERPINB6 activates the PI3K/AKT/mTOR pathway—a known driver of TMZ resistance via enhanced DNA repair and anti‐apoptotic signalling [29, 30]—GA‐mediated inhibition of SERPINB6 may suppress these pro‐survival mechanisms, thereby sensitising glioma cells to TMZ [31, 32].