Cannabinoids have been reported to activate autophagy by inducing endoplasmic reticulum stress and inhibiting the Akt/mTORC1 complex in glioma [36].Increased autophagy induces apoptosis in solid cancer cells [37–39], pointing the way to the exploitation of CBR ligands as effective inducers of cancer cell death. Here, CNR1 is linked to central nervous system cancer.