Recent studies have shown that zinc finger E-box binding homeobox 1 (Zeb1) upregulates the expression of key glycolytic enzymes (HK2, PFKP, and LDHA), leading to lactate accumulation and increased histone lactylation, thereby increasing chromatin accessibility and cell lineage plasticity and promoting the development of prostate neuroendocrine carcinoma [16]. This evidence concerns the gene ZEB1 and prostate neuroendocrine neoplasm.