However, the knockdown of the lncRNA STEAP3-AS1 significantly reduced the binding of BRG1, ERG, P300, and H3K18la, indicating that the lncRNA STEAP3-AS1-mediated BRG1/ERG/P300 complex regulates the H3K18la-specific activation of MMP9, which is a key to colorectal cancer liver metastasis. The gene discussed is ERG; the disease is colorectal cancer.