FUBP1 and neoplasm: Recent studies have shown that the lncRNA NR_109 mediates chromatin remodelling in M2-like macrophages, competing with JVT-1 to bind to the C-terminal domain of upstream element binding protein 1 (FUBP1), preventing the ubiquitin-mediated degradation of FUBP1, activating c-Myc transcription, promoting polarization of M2-like macrophages, and supporting tumour cell proliferation and metastasis in vitro and in vivo [7].