CDK4 and cancer: Studies have shown that BRG1-P300 complexes are accompanied by poly ADP-ribose polymerase 1 (PARP1), which is codistributed at the promoters of genes such as CDK4, LIG1, or NEIL3 to ensure an open chromatin structure that allows a low histone density, which is responsible for cancer cell growth and the elimination of DNA damage [48].