Using bioinformatic analysis, we screened eight candidate miRNAs involved in PTEN regulation in BLCA (Fig. 7A), and their expression was assessed by modulating ERα expression in BLCA cells, following which we identified miR-642a-5p and miR-5754-3p as promising candidates (Fig. 7B). This evidence concerns the gene PTEN and bladder transitional cell carcinoma.