We selected four different cell lines: B16-F1 mouse melanoma cells to reflect the clinical application of ECT in cutaneous tumors and skin metastases18,19; C2C12 mouse myoblasts as a model for GET24; CHO-K1 cells as a model of cells with low endogenous ion channel expression25; and NS-HEK cells with stable expression of NaV1.5 channels26,27 to explore the potential role of sodium channels in the observed outcomes. This evidence concerns the gene SCN5A and melanoma.