In addition, serum LRG1 was able to well distinguish RA patients from health controls (AUC = 0.795); moreover, with a cutoff level of 30 μg/mL, LRG1 showed diagnostic utility for RA, with a sensitivity of 0.885, a specificity of 0.550, and a Youden index of 0.435. This evidence concerns the gene LRG1 and rheumatoid arthritis.