For example, the plasma resistin level is positively correlated with disease activity and can predict 5-year radiological progression in RA patients treated with methotrexate, sulfasalazine, hydroxychloroquine, or prednisolone with or without infliximab [11]; the serum JNK pathway-associated phosphatase (JKAP) level is inversely associated with multiple inflammatory and disease-activity-related indexes, and its increase over 24 weeks is related to the response to etanercept in RA patients [12]. The gene discussed is RETN; the disease is rheumatoid arthritis.