Additionally, proteins such as ENO1 (β = 0.47, P = 2.6 × 10−25) and NPTXR (β = −0.72, P = 5.8 × 10−25), involved in glycolysis and synaptic functions, respectively, were also associated with FTD, highlighting metabolic dysregulation and synaptic dysfunction22. Here, NPTXR is linked to frontotemporal dementia.