In proteins uniquely associated with FTD, we identified significant enrichment of pathways associated with ‘Signaling by interleukins’ (P = 1.1 × 10−3) and ‘Platelet degranulation’ (P = 6.4 × 10−3), characterized by the proteomic alterations in cytokine receptors (IL-2, IL-18, IL-1F10 and IL-21R). This evidence concerns the gene IL18 and frontotemporal dementia.