We also validated additional proteins reported in a recent large-scale AD proteomic plasma study: NPTXR (β = −0.62, P = 4.9 × 10−136), SPC25 (β = 0.58, P = 7.7 × 10−99), LRRN1 (β = 0.47, P = 1.1 × 10−71), MAPT (β = 0.07, P = 4.7 × 10−3) and ACHE (β = 0.41, P = 4.3 × 10−62)10. The gene discussed is ACHE; the disease is Alzheimer disease.