Further leveraging the GNPC dataset, we performed plasma proteome profiling of 2,929 AD, 75 FTD, 169 PDD, 422 PD, 230 ALS and 6,099 nonimpaired control individuals with and without an APOE ε4 allele (Supplementary Table 1). The gene discussed is APOE; the disease is amyotrophic lateral sclerosis.