Thirty-eight targets exhibited significantly decreased abundance in ALS, including two aptamers targeting ART3, an ADP-ribosyltransferase enriched in skeletal muscle, as well as additional proteins linked to growth factor signaling and/or extracellular matrix composition (ANTXR2, CRTAC1 and RGMA). This evidence concerns the gene ANTXR2 and amyotrophic lateral sclerosis.