Top proteins with high feature importance in the clinical impairment signature (Fig. 1k and Supplementary Table 8) again highlighted ACHE and NPTXR as well as additional targets linked to neuroplasticity (EPHA4 and CNTFR) and immune activation (MSMP and KLK3), underscoring their potential for transdiagnostic dementia staging. The gene discussed is MSMP; the disease is dementia.