In pHV-infected iPSCs, quite a few upregulated DEGs are implicated in methylation (n = 11; NSUN7, PRDM15, SMYD4, CMTR2, CARNMT1, FAM86C2P, MTAP, METTL3, METTL15, METTL7A, TPMT) and WNT signalling (n = 12; LYPD6, PRDM15, SMURF2, ADGRA2, DAAM2, EDA, ROR2, RECK, SEMA5A, TTC21B, TGFB1, ZEB2), partially characteristic of cancer development. The gene discussed is SMURF2; the disease is cancer.