In pHR-infected iPSCs, quite a few upregulated DEGs are implicated in response to DNA damage stimulus (n = 21; BCL3, BCL6, CDKN2AIP, CTC1, DDX11, DCLRE1B, POLK, POLQ, FANCF, FAM111A, MICA, RAD52, SETD7, SLF1, SUV39H1, WRN, HROB, IRF7, MCM8, VAV3, ZC3H12A) and activation of GTPase activity (n = 11; GMIP, RUNDC1, TBCK, TBC1D2, TBC1D22B, USP6NL, WNT5A, NEDD9, SGSM1, SLC27A4, SYDE1), partially suggestive of protection against cancer progression [33]. The gene discussed is POLK; the disease is cancer.