Interestingly, administration of CS/Res/Se-NPs-5 and/or CS/Res/Se-NPs-10 as well as standard Res-100 or Met-100 resulted in a remarkable restoration of GSH and SOD levels and a significant elevation of CAT, GPx, GR, and GST enzymatic activity compared to T2DM-induced mice (p < 0.05). Here, SOD1 is linked to type 2 diabetes mellitus.