In contrast, treatment with CS/Res/Se-NPs-5 or CS/Res/Se-NPs-10, as well as standard Res-100 or Met-100, significantly reduced FBG levels (3.5, 4, 3.7, and 3.1-fold decrease, respectively) and insulin concentrations compared to the T2DM-induced mice (p < 0.05). This evidence concerns the gene INS and type 2 diabetes mellitus.