Interestingly, previous studies have shown that APOE was downregulated in OA cartilage and Apoe deficiency was connected to the development of OA (Archer et al, 2016; Collins-Racie et al, 2009; de Munter et al, 2016; Farnaghi et al, 2017), indicating the protective role of Apoe in OA. The gene discussed is APOE; the disease is hyperinsulinemic hypoglycemia, familial, 4.