ABHD11 and cancer: Prior studies in cancer cell lines showed that ABHD11 deficiency leads to 2-OG accumulation, which drives the formation of the l-enantiomeric (S) form of 2-hydroxyglutarate (2-HG) and subsequent inactivation of 2-OGDDs involved in the HIF pathway (prolyl hydroxylases, PHDs), histone marks (for example, lysine demethylases, KDMs) and DNA methylation (for example, ten-eleven translocation,TET enzymes)16,22,23.