Furthermore, the remarkably low incidence of MDS (including advanced MDS and early-stage MDS) in early childhood (7.2% of the cohort by age 6 years) with a steep increase during school-age, reaching 45.5% by age 12 years suggests that early hematopoiesis remains relatively preserved despite GATA2 deficiency. This evidence concerns the gene GATA2 and myelodysplastic syndrome.