A recent study has reported that TRIM28 SUMOylated NUP37 at Lys114/118/246 to inhibit K27-linked polyubiquitination of NUP37, which augmented NUP37 protein level and accelerated lipid synthesis and the progression of HCC.17 TRIM28 directly interacted with PD-L1 and prevented PD-L1 degradation through inhibition of PD-L1 ubiquitination. The gene discussed is NUP37; the disease is hepatocellular carcinoma.