PKM and colorectal carcinoma: Our previous study revealed that DDX39B R319 residue around P322 residue is indispensable for PKM2 binding and for DDX39B-triggered PKM2 nuclear accumulation and proliferation in CRC cells.38 These results suggest that this hydrophobic pocket within the helicase C-terminal domain of DDX39B may facilitate the stable interactions between DDX39B and other proteins.