DExD-box helicase 39B (DDX39B, also known as BAT1 and UAP56), a member of DEAD box (DDX) RNA helicase family, has been demonstrated to participate in the development of various diseases through the regulation of mRNA transcription, splicing and nuclear export.9–11 In addition to their canonical RNA regulatory functions, DDX family has recently been confirmed to participate in tumor development via protein‒protein interaction. Here, AKR1C3 is linked to neoplasm.