MECOM amplification was analysed in publicly available pan-cancer TCGA genomic database, which revealed more than 20% copy number amplification of MECOM in ovarian epithelial tumors, only second to esophageal squamous cell cancers (https://www.cancer.gov/tcga) (Supplementary Fig. 1A) [36, 37]. Here, MECOM is linked to esophageal squamous cell carcinoma.