PKMYT1 and familial pancreatic carcinoma: Our findings, corroborated by figures (Figs. 2I–K, S1C, D), indicate that either the silencing of PKMYT1 or administration of RP-6306 disrupts the G2/M checkpoint integrity in pancreatic cancer cell lines, leading to untimely and unregulated entry into mitosis coupled with an accumulation of unresolved DNA damage, culminating in mitotic catastrophe [43].