To probe the correlation between the serine/threonine kinase gene family and the pathogenesis of pancreatic adenocarcinoma (PAAD), we conducted an analysis on the expression levels of 399 serine/threonine kinases in pancreatic cancer versus adjacent normal tissues, utilizing data from the TCGA database (Fig. 1A, Table. Here, MARK2 is linked to pancreatic adenocarcinoma.