Additionally, leveraging on the differentially-expressed genes identified from bulk-RNA seq of parental and resistant cell lines, we uncovered two key gene expression signatures, RESIST-M1 (where RESIST-M denotes RESIstance-Induced SignaTure for CRC Metastasis) characterized by high expression of SERPINE1 and SMARCD3; and RESIST-M2, defined by genes involved in cholesterol biosynthesis (SC5D, FDPS, MVD, HMGCS1, HMGCR, CYP51A1, ACAT2). This evidence concerns the gene HMGCS1 and colorectal carcinoma.