In this study, we show that not only SERPINE1, but also high expression of RESIST-M1 (SERPINE1, SMARCD3) and low expression of RESIST-M2 (SC5D, FDPS, MVD, HMGCS1, HMGCR, CYP51A1, ACAT2) genes were significantly enriched in the CMS4 subtype of CRC, which is strongly associated with poor prognosis and aggressive disease. Here, SERPINE1 is linked to colorectal carcinoma.