A familial cause is implicated in about 20%–35% of DCM cases.101 Carriers of specific genetic variants associated with DCM, for instance desmosomal, lamin A/C, filamin C, and titin-truncating variants, carry an increased risk of SCD.102,103 This may in part be explained by the varying distribution pattern of LGE underlying the genetic substrate. Here, TTN is linked to familial dilated cardiomyopathy.