LMNA and familial dilated cardiomyopathy: A familial cause is implicated in about 20%–35% of DCM cases.101 Carriers of specific genetic variants associated with DCM, for instance desmosomal, lamin A/C, filamin C, and titin-truncating variants, carry an increased risk of SCD.102,103 This may in part be explained by the varying distribution pattern of LGE underlying the genetic substrate.