Cardiac protein expression of BDH1 (converts βOHB into acetoacetate; Figure 3) is decreased in mice with HFD/low-dose STZ-mediated T2D [74], whereas cardiac enzymatic activity of SCOT (converts acetoacetate into acetoacetyl CoA; Figure 3) is increased in both mice with HFD/low-dose STZ-mediated T2D and Goto-Kakizaki rats [74,76]. This evidence concerns the gene BDH1 and type 2 diabetes mellitus.