Mahajan et al. (2022) [9] identified 97 candidate effector genes, including ADCY5 and TCF7L2, based on circulating plasma proteins (pQTL) and gene expression (eQTL) in diverse tissues, while Vi nuela et al. (2020) [8] focussed on expression in human pancreatic islets and showed colocalization between genetic variants influencing T2D or glycemic traits and 47 islet cis-eQTL, including ADCY5, DGKB and TCF7L2. The gene discussed is ADCY5; the disease is type 2 diabetes mellitus.