Consistent with this expectation, multivariable MR using the multivariable inverse-variance weighted method implemented within the R package MendelianRandomization provided no significant evidence of causal effects of gene expression on T2D for FADS1, FADS2 and MYRF (p-values 0.610, 0.381, 0.232 respectively). This evidence concerns the gene FADS1 and type 2 diabetes mellitus.