Interestingly, univariate analysis using the inverse-variance weighted method did show some evidence for a causal effect of MYRF gene expression on T2D (p-value 0.012), although no significant effects were seen at FADS1 and FADS2 (p-values 0.292 and 0.550 respectively). The gene discussed is FADS2; the disease is type 2 diabetes mellitus.