This led to the idea that high FSH was not only permissive to perimenopausal bone loss, but also underpinned obesity and memory loss, and could, in fact, also explain the higher lifetime risk, progression rate, and symptom burden of Alzheimer’s disease (AD) in postmenopausal women (8). The gene discussed is BRD2; the disease is obesity due to melanocortin 4 receptor deficiency.