NFAT5 and colitis: To confirm the main findings of this study in another model of experimental colitis that more closely resembles the development of human IBD, we mated Il10-homozygous KO (Il10–/–) mice with Nfat5-heterozygous KO (Nfat5+/–) mice (Supplemental Figure 9) and compared the development of spontaneous colitis between the Nfat5+/– and Nfat5+/+ littermates.