NFAT5 and colitis: As shown in Figure 8, D and E, Nfat5+/– mice with specific overexpression of Hsp70 in IECs (Hsp70IEC-TGNfat5+/–) had less severe colitis than did Nfat5+/– mice without Hsp70 overexpression (Hsp70WT Nfat5+/–), demonstrating that epithelial HSP70 contributed to the attenuation of DSS-induced colitis accelerated by Nfat5 deficiency.